June 12th - 16th 2017
Château du Liebfrauenberg, Alsace, France



2nd European Advanced School for Mouse Phenogenomics

The mouse phenogenomics and the good practices regarding the use of mouse models for scientific research

Registrations are closed

 

View 2015 edition website

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Partners

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  • 24 experts from European landscape of the mouse phenogenomics field
  • An open yet priviledged place for exchanges and discussions of major on-going works, scientific and methodological issues
  • Share knowledge and expertise, transfer new concepts and innovative methods
  • Gain crucial skills required to use as best mutant mice 

The mouse phenogenomics

The mouse phenogenomics is currently the key way through modelling of disease in biomedicine. phenominSchool2017_c.jpg The mouse, first lab mammal to have its genome sequenced, is the most animal model used in laboratory to improve knowledge regarding how gene are involved in health and disease. The understanding of the molecular pathways the gene control is crucial to the understanding of the mechanisms of pathogenesis, the discovery of new targets and preclinical human therapeutic applications. PHENOMIN, French specialist in the generation of genetically modified mice, and their clinical characterization in vivo (anatomical, physiological and behavioural phenotypes) is actively involved in the international effort to annotate the genome of mammals, and particularly functional annotation of 20 000 coding genes identified in mice, which actually make up only 1.5% of its genome. 

PHENOMIN supports researchers who use mouse models by giving us the opportunity to take part of the 2nd Edition of the Advanced School in Mouse Phenogenomics. 

 

The 2017 school will continue to build on the success of the previous session !

Affiche TRONQUEE-ET2017.png Would you like to learn how to choose, create and analyse your best mouse model?

Do you have a sufficient background in mouse functional genomics to lead as best your research?

Then, come to the heart of Europe to be involved - together with other students and researchers from all over the world - in opened discussion, in constructive analysis of your own research and in building conceptual scientific advances.

This unique international event will provide the attendees with an innovative program focused on the best practices in the use of the mouse model for biomedical and basic research; this program also addresses the item of continuing professional education consistent with the new European directive requirement for lab animal protection in experiments.

  • The school covers the different fields of mouse phenogenomics, ranging through 5 topics from state-of-the-art mouse genetics, mutagenesis, mouse colony management, phenotyping human diseases and data management (statistical approaches).
  • Importantly, some freely-available resources that link model organism genes to human diseases will be presented to promote a better understanding of the mammalian genome. It is a very completed program to overview all the transversal connection between each topic.

The school will provide a wealth of information on good practices in the use of mouse model (experimental design, ethics, regulations, analysis, data and resources ...) to support attendees in their research. 

 

Advanced School

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Likely to the previous edition, the program consists of invited speakers' talks, work sessions on selected scientific and/or methods issues.

  • Accelerate the transfer of concepts and innovative methods regarding the mouse genetics, mutagenesis, phenotyping, mouse colony management, and archiving- distribution lines of genetically modified mice.
  • Support participants in the use of current European and international free resources on mouse phenogenomics: cryopreservation, distribution and phenotyping data for lines already characterized and available to the scientific community

Mornings are devoted to seminars whereas afternoons are devoted to "practical sessions" needing the active attendees' participation (work group, debate, round table,..).

 

 

The target audience consists of engineers and/or clinicians and/or researchers who directly or indirectly use mouse as animal model for scientific research. We encourage both industrial and academic researchers, postdocs and PhDs from all Europe to attend this school. The school involves French and European major infrastructures, thought its INFRAFRONTIER partnership.

45 participants could attend at the school.

 

Meet the speakers and experts

One of the aims of the PHENOMIN school is to provide the unique opportunity for PhDs and young postdocs to discuss in details about their research with experts as well as with each other. 

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  • The courses are based on scientific international projects dedicating to the annotation of the genome of mammals and mouse phenogenomics.
  • In addition, the welfare assessment of genetically modified mouse models and ethical considerations in experimental design will be highlighted by an original and instructive workshop. The new European requirements for animal testing will be addressed too.
  • The invited speakers' talks  include seminars (25 or 50 minutes) on specific topics that allow discussion with the audience (5 or 10 minutes questions & answers). Attendees will be given opportunities for informal chats through lunches and dinners with speakers and experts. 
  • An abstract submission is required and consists of recently published or unpublished research or clinical case presentations or new solutions for management/husbandry problems. 
  • Working sessions in groups are scheduled to answer the highlighted issues from participants (attendees expectations will be declined in the registration form). 

 

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By this way, and by emphysing the time frame for free time, discussions and exchanges, the school promises to accelerate the sharing of conceptual scientific advances and transfer of innovative methods and techniques in the field of animal testing, and more specifically the use of mice in biomedical research, including the design of experimental protocols until its realization and data analysis.

24 invited experts will attend the school. European speakers, involved in INFRAFRONTIER infrastructure, will join us as well.

 

PHENOMIN School Committee

Scientific committee

Cécile Frémond

Cécile Frémond

PhD, Veterinarian, Director of the "Centre de trangenèse, archivage et modèle animal" or the Center of Transgenesis, Archiving and Animal Model (TAAM), CNRS

Yann Hérault

Yann Hérault

PhD, Director of the "Institut Clinique de la Souris" or Mouse Clinical Institute (ICS), INSERM-CNRS-University of Strasbourg

Bernard Malissen

Bernard Malissen

PhD, Director of the "Centre d'immuno-phénogénomique" or the Center of Immuno-Phenogenomics (CIPHE), INSERM-University of Aix-Marseille

Steering committee

Abdel Ayadi

PhD, Head of the Mouse services department (ICS)

Isabelle Goncalves

DMV, Veterinarian and manager of ethic and welfare (ICS)

Patrick Reilly

PhD, Head of the phenotyping department (ICS)

 

 

Elodie Bedu

PhD, Manager for business development and training (ICS)

Guillaume Pavlovic

PhD, Head of the genetic engineering and model validation department (ICS)

Mohammed Selloum

PhD, Project Coordination of European programs (ICS)

 

Marie-Christine Birling

PhD, Associate Head of the genetic engineering and model validation department (ICS)

Tania Sorg

PhD, Chief operating officer (ICS) 

Laurent Vasseur

Head of management information department (ICS)

Major topics of the program

Monday June 12th

Mouse genetics

Tuesday June 13th

Mutagenesis

Wednesday June 14th

Functional tests in mice models
Advancing human health

Thursday June 15th

Animal Science
Ethics and welfare

Friday June 16th

Advanced programs in mouse phenogenomics, initiatives and resources

The school will boost the emergence of new themes and will accentuate interdisciplinary in scientific survey of PhDs and active staff in the field of functional and clinical studies. In this context, the thematic school allows to provide a friendly environment that fosters strong connections between students, young researchers who would never have the opportunity to meet, and so a warm relationship between researchers, and the organizers and stakeholders. The main objective is to strengthen the relationship between doctoral education and scientific research. Bringing together, the school will structure the scientific community using mice as an experimental model around the infrastructure PHENOMIN and many networks in which it participates actively (CELPHEDIAINFRAFRONTIERIMPC...).

Schedule and speakers

First day / departure on June 12th 2017: Bus leaves Strasbourg train station to school location at 11:00 AM.

Last day / return on June 16th 2017: Bus leaves school location to Strasbourg train station at 2:00 PM.

Download Program in PDF

 

Day 1: Mouse genetics

Basic overview of laboratory mouse genetics / Advanced mouse genetics programs: European and international new programs.

11:00 AM Bus leaves Strasbourg's train station to school location
12:00 PM - 1:00 PM Welcome
1:00 PM - 2:00 PM Lunch
2:00 PM - 2:30 PM Introduction (Y. Hérault, PHENOMIN-ICS)
2:30 PM - 3:30 PM Laboratory Mouse Genetics: basic overwiew (L. Montoliu, CNB-CSIC)
3:30 PM - 4:30 PM Advanced Mouse Genetics Programs (Y. Hérault, PHENOMIN-ICS)
4:30 PM - 5:00 PM Break
5:00 PM - 7:00 PM Workshop: group 1 - 15 participants max/3-4 experts. Short presentation of scientific project and scientific issue/question/problematic 
7:00 PM - 7:30 PM Free 
  Dinner

 

Day 2: Mutagenesis
CRISPR 9 genome editing in vivo / Mouse model for decipher the immunity/ Mouse models for cancer research
8:30 AM - 9:00 AM Mutagenesis: good practices (G. Pavlovic, PHENOMIN-ICS)
9:00 AM - 10:30 AM CRISPR/Cas9 and other nucleases -Applications and future perspectives (MC. Birling, PHENOMIN-ICS and L. Teboul, MRC)
10:30 AM - 11:00 AM Break
11:00 AM - 12:00 PM The use of viral vector for mouse mutagenesis and/or for delivery of gene editing by nuclease (F. Piguet, IGBMC)
12:00 PM - 1:00 PM Genetic modification and its impact on phenotyping date, i.e, mouse model validation (G. Pavlovic, PHENOMIN-ICS)
1:00 PM - 2:00 PM Lunch
02:00 PM- 03:00 PM Mutagenesis to decipher the mouse immune system (B. Malissen, PHENOMIN-CIPHE) 
3:00 PM - 4:00 PM Mouse model for cancer (J. Jonkers, NKI)
4:30 PM - 5:00 PM Break
5:00 PM - 7:00 PM Workshop: group 2 - 15 participants max/3-4 experts. Short presentation of scientific project and scientific issue/question/problematic 
7:00 PM - 7:30 PM Free 
  Dinner

 

Day 3: Functional tests in mouse models / Advancing human health
Standardized exploration of physiological functions, scientific and ethical considerations, study design, analysis and data management, alternative imaging method tests / Preclinical approaches with mouse models, a first step toward the man, interest and limits
8:30 AM - 9:00 AM

Functional exploration in mouse models: good practices (T. Sorg , PHENOMIN-ICS)

9:00 AM - 9:30 AM

Strategies for improving reproducibility with in vivo studies (P. Reilly, PHENOMIN-ICS)

9:30 AM - 10:00 AM Statistical analysis (L. Vasseur, PHENOMIN-ICS)
10:00 AM - 10:30 AM Imaging and pre clinical applications (S. Lerondel, PHENOMIN-TAAM)
10:30 AM - 11:00 AM Break
11:00 AM - 11:30 AM Primary phenotyping of mouse embryos (O. Wendling, PHENOMIN-ICS)
11:30 AM - 12:00 PM How to phenotype new born and juvenil mice ? (E. Durant, PhenoPups)
12:00 PM - 12:30 PM NeuroBehavior and sensory organ phenotyping (H. Meziane, PHENOMIN-ICS)
12:30 PM - 1:00 PM Aging phenotyping (P. Potter, MRC)
1:00 PM - 2:00 PM Lunch
2:00 PM - 4:00 PM Workshop: group 3 - 15 participants max/3-4 experts. Short presentation of scientific project and scientific issue/question/problematic 
4:00 PM - 5:00 PM Break
5:00 PM - 6:30 PM Retransmission of Informal discussions from workshop session in groups: more important feed back to be adressed

6:30 PM 

Social event (on site)
  Diner

 

Day 4: Animal Science / Ethics and welfare
Health, impact on functional studies, increasing safe, colony management and genetically drift / Impact of the mouse gut microbiota / Good practice for good results Workshop: welfare assessment of genetically engineering mouse models
9:30 AM - 10:30 AM Tips, Tools and Techniques to secure your mice projects (A. Ayadi, PHENOMIN-ICS) 
10:30 AM - 11:00 AM Break
11:00 AM - 11:30 AM Immunophenotyping (M. Malissen, PHENOMIN-CIPHE)
11:30 AM - 12:30 PM Heath status, bioconfinment, and microbiota impact on phenotyping (C.Fremond, PHENOMIN-TAAM)
12:30 PM - 1:00 PM Crucial complementary aspects of functional analysis: anatomo pathology of the mouse (H. Jacobs, PHENOMIN-ICS)
1:00 PM - 2:00 PM Lunch
2:00 PM - 3:00 PM The Collaborative Cross, applied to the infectious disease susceptibility  (X. Montagutelli, Institut Pasteur)
3:00 PM - 4:00 PM Animal models are valid to uncover disease mechanisms (Wurst W, HMZ1)
4:00 PM - 4:30 PM Welfare assessment of genetically engineered mouse models (I.Goncalves, PHENOMIN-ICS) 
4:30 PM - 5:00 PM Break
5:00 PM - 7:00 PM Workshop: "Ethics and welfare assessment of genetically engineered mouse models" - Practical illustrations- workgroup session 
7:00 PM- 7:30 PM Free
  Dinner

 

Day 5: Advanced programs in mouse phenogenomics, initiatives and resources
National, European and International Integrated Resources: by, for and available to the scientific community  / Improving bioscience reporting and data robustness: ensure the reproducibility of pre-clinical studies
8:30 AM- 09:00 AM European ressources : General overview (Mohamed Selloum, PHENOMIN-ICS)
9:00 AM- 09:30 AM Gencodys consortium and mouse models for cognitive dysfunction (Y. Hérault, PHENOMIN-ICS)
9:30 AM- 10:00 AM Infrafrontier Research Infrastructure (M. Hagn, HMZ2)
10:00 AM- 11:00 AM Data integration (AM. Mallon, MRC)
11:00 AM- 11:30 AM Break
11:30 AM- 12:00 PM Improving Bioscience Research Reporting: The ARRIVE Guidelines  (I. Goncalves, PHENOMIN-ICS)
12:00 PM - 01:00 PM Round table: debrief, satisfaction survey, opened discussions on 3 selected major points.
1:00 PM - 2:00 PM Lunch
2:00 PM Bus leaves school location to Strasbourg’s train station

 

Fees

  • PhD applicants: 470€ 
  • Applicants from governmental institutions: 780€ 
  • Applicants from private institutions or companies: 2180 € 

Free of charge for CNRS agents and CNRS PhD students
Free of charge for PhD students from the University of Strasbourg

Location

Château du Liebfrauenberg
220 rue du Château, 67360 Goersdorf, France
+33 3 88 09 31 21
48.957976, 7.766174

CONTACT

COORDINATORS:

  • Elodie Bedu
  • Joëlle Pensavalle

advanced-school@phenomin.eu

WEBMASTER:

  • Johan Leyritz

webmaster@phenomin.eu